Springer Protocols: Abstract: Bioinformatics Approaches for Studying Untranslated Regions of mRNAs

Bioinformatics Approaches for Studying Untranslated Regions of mRNAs

By: Paramjeet S. Bagga³

Abstract

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Interactions between RNA-binding proteins and cis-acting elements in the 5′- and 3′-untranslated regions (UTRs) of transcripts are responsible for regulating essential biological activities, such as mRNA localization, mRNA turnover, and translation efficiency. This chapter introduces some of the publicly available free bioinformatics resources, including software tools and databases, which can be used for predicting, mapping, and characterizing regulatory motifs found in the eukaryotic mRNA-untranslated regions.

Affiliation(s): (3) Bioinformatics Department, School of Theoretical and Applied Science, Ramapo College of New Jersey, Mahwah, NJ, USA

Book Title: Post-Transcriptional Gene Regulation

Series: Methods in Molecular Biology | Volume: 419 | Pub. Date: Dec-21-2007 | Page Range: 1-21 | DOI: 10.1007/978-1-59745-033-1_1

Subject: Genetics/Genomics

Key Words: UTR - bioinformatics of UTR - RNA bioinformatics - untranslated regions - mRNA cis-acting elements - RNA regulatory motifs - RNA motif prediction - RNA motif databases

References

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